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KMID : 1123920040180010230
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 1 p.230 ~ p.235
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Immunomodulatory activity of phytoprotein isol Acanthopanax senticosus : Regulation of CTL responses and activation of macrop
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Lee Seok-Won
Lee Soo-Jin
Park Jeon-Ran
Kim Ha-Na
Ahn Kyoo-Seok
Kim Jung-Hyo
Baek Nam-In
Kim Sung-Hoon
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Abstract
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We previously reported that the phytoprotein extracted from Acanthopanax senticosus (PA) had anti-carcinogenic anti-metastatic activity via increase of inhibition of gap junctional intercellular communication. In the present study investigated the immunomodulatory mechanism of phytoprotein isolated from the stem bark of Acanthopanax sentic (PA). PA was found to significantly stimulate macrophages producing TNF-α and IL-1β in vitro. It also showed tumori activity indicating that PA had the ability to stimulate macrophage directly. Moreover, PA induced the CDB/sup +/ CTL cy responses to recognize antigen on the B16-BL6 melanoma cells. Treatment of PA with B16-BL6 melanoma cells increased the proliferation of splenocytes compared with untreated control. These results demonstrate that PA immunomodulatory activity suggesting a useful anti-tumor agent applicable to treatment and prevention of cancer.
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KEYWORD
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Acanthopanax senticosus, phytoprotein, macrophage, Cytotoxic T lymphocyte, cytokines, TNF-α, IL-1β
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